Synthetic methodology development and reaction asymmetry

Group leader: Andrew Smith

Royal Society University Research Fellow

Research overview

 

Synthetic organic chemistry has applications that span the breadth of contemporary science, ranging from materials chemistry to chemical biology. Our research focuses upon the development of new, small molecule, designer organic catalysts and novel asymmetric processes, the advancement of a mechanistic understanding of these transformations, and their application in synthesis. Current projects include the development of new catalytic cascade reaction processes using NHCs and isothioureas for the construction of stereodefined chiral building blocks with application to target products of medicinal interest. Alternative projects include the development of asymmetric pericyclic cascades for the synthesis of oxindoles.

 For more information see the ADS Group Website: http://chemistry.st-and.ac.uk/staff/ads/group/

Publications

Arnold, PL, Kerr, RWF, Weetman, C, Docherty , SR, Rieb, J, Cruickshank, FL, Wang, K, Jandl, C, McMullon, MW, Pöthig, A, Kühn, FE & Smith, AD 2018, 'Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes' Chemical Science, vol. Advance Article. https://doi.org/10.1039/C8SC03312A

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.