ABSTRACT. — We are living in times where there is considerable debate over what sex and gender are and who gets to be of what sex and what gender. These are questions that impact people’s lives greatly, some more than others. They are metaphysical questions but they also concern what principles we should be guided by when allocating resources, services, and protections to people with potentially different needs. There are also methodological questions in the vicinity. I present a conception of sex and gender and their relation and suggest a certain approach to navigating some of the political and material differences. I call that approach “ontic descent”.