Research in the lab is focused on dissecting the molecular biology of eukaryotic chromosomal DNA replication and genome stability, primarily using two contrasting genetically-tractable model systems, the eukaryotic fission yeast Schizosaccharomyces pombe and the halophilic euryarchaeon Haloferax volcanii. In addition to this, we also study the replication machinery of the parasitic protozoan Trypanosoma brucei and the marine giant virus CroV. We use a variety of methods to address questions of protein structure and function within the chromosome replication apparatus, including genetics and molecular biology, biochemistry and bioinformatics.
These pages provide details of ongoing projects in the lab, lists of publications and lab members, details of how to apply to join the lab, and some useful links. Click on the topics on the right to access the desired information.