Sunday 12th January 2002
17.00 An arrivals desk will be in place in the Physics Building (also where lectures will be held) to greet members with a registration pack. See the map.
Opening highlight lecture (Chair Jim Naismith)
18.00 - 19.00 Chris Walsh , Harvard "Antibiotic Glycosyl Transferases in the Biosynthetic Pathways for Glycopeptide and Aminocoumarin Antibiotics
"
Dinner
20.00 Scores Hotel.
Monday 13th January 2002
Session 1 Oxygen Activation I (Chair Chris Schofield)
08.40 Carrie Wilmot, Minesota, "Oxygen activation in a copper-containing amine oxidase"
09.20 Nigel Scrutton, Leicester, "Diflavin reductases and oxygen activation"
10.00 Coffee
10.40 Simon Daff, Edinburgh, "NO synthase: A substrate-controlled conformational seesaw"
11.20 Luet Wong, Oxford, "Molecular recognition engineering in P450cam catalysis"
12.00 Sandwich Lunch & Posters
Session 2 Oxygen Activation II (Chair Nigel Scrutton)
14.00 Mike McPherson, Leeds, "Cofactor processing and catalysis in galactose oxidase"
14.40 So Iwata, Imperial, "Structural studies on the respiratory complexes"
15.20 Chris Schofield, Oxford, "Mechanism of Dioxygen Sensing In the Hypoxic Response"
16.00 Coffee
Highlight lecture (Chair John Ingledew)
16.30 - 17.30 Steve Sligar, Chicago, "Heme-Oxygen Reactive Intermediates: Catalysis by the Two-Step"
17.30 Reception in Poster area
Highlight lecture (Chair Jim Naismith)
18.30 - 19.30 John Blanchard, New York,
"What can Structure tell us about In Vivo Function?
The case of the Aminoglycoside Resistance Genes"
Conference Dinner
20.00 Scores Hotel. Speaker: Steve Chapman, Edinburgh
Tuesday 14th January
Session 3 Carbohydrates, peptides and lipids (Chair John Blanchard)
08.40 Gideon Davies, York, "The reaction coordinate of glycosyltransfer: Structural analysis of glycosidases and glycosyltransferases"
09.20 Walter Ward, AstraZeneca,
"The Molecular Mechanism for Inhibition of HMG-CoA Reductase by Rosuvastatin"
10.00 Coffee
10.40 Jim Naismith, St. Andrews, "Unusual carbohydrate chemistry"
11.20 Bill Hunter, Dundee, "Structure and reactivity in the non-mevalonate pathway of
isoprenoid biosynthesis"
12.00 Lunch/posters
Session 4 Small molecule recognition and activation (Chair Steve Chapman)
13.20 Katy Brown, Imperial, "Twists and Turns: A Tale of Two Shikimate Pathway Enzymes"
14.00 John Coggins, Glasgow, "Experiences with the shikimate pathway enzymes as targets for rational drug design"
14.40 David Lawson, John Innes, "A two-faced molecule offers NO explanation:
the proximal binding of nitric oxide to heme"
15.20 Coffee
Highlight lecture (Chair Steve Chapman)
15.50 - 16.50 Tom Blundell, Cambridge,
"Structural biology of microbial biosynthesis: pantothenate and other systems"
