Biomedical Sciences Research Complex Mass Spectrometry and Proteomics Facility (not solely School of Chemistry instruments)

• A Waters LCT ESI mass spectrometer and 2795 HPLC with Photodiode Array Detector This instrument is used for intact protein mass analysis and small molecule analysis by infusion and LC-MS.
• An ABSciex 4800 MALDI TOF/TOF Analyser This instrument is predominantly used to identify proteins by analysis of proteolytic digests (normally trypsin) by MS and MSMS fragmentation. PTMs and other modifications can also be observed and mapped by interpretation of the MSMS fragmentation patterns. The instrument is also used for intact protein mass analysis and some polymer and small molecule analysis.
• A Dionex UltiMate 3000 nanoflow HPLC and Probot MALDI target spotter allows LC-MALDI spotting which is analysed using the 4800 instrument.
• An ABSciex QStar XL, ESI MSMS mass spectrometer and Dionex, UltiMate nanoflow HPLC This MSMS instrument complements the MALDI instrument and is used for the analysis of proteolytic digests of more complex mixtures or weaker samples than the MALDI instrument. Techniques include GeLC analysis (analysis of a series of sections from 1D SDS-PAGs instead of individual bands), and iTRAQ quantitation. PTMs and other modifications can also be mapped. Due to time constraints this instrument is run almost exclusively in nanoLC-ESI MS/Msmode.  However, static nanospray of intact proteins is also possible.
• Genomic Solutions, ProGest and ProPrep, in-gel digestion robots These instruments carry out automated in-gel proteolytic digests from 1 and 2D SDS-PAG bands and spots. 

Website: Biomedical Sciences Research Complex Mass Spectrometry and Proteomics Facility

Email: Dr C Botting

Tel: 01334 467195  

St Andrews hosts two computer clusters, providing 292 cores for high-end
computing in chemistry, as part of the EaStCHEM research computing facility

Email: Dr Herbert Fruchtl

Tel: 01334 467261/463750

For other matters please contact the School Computing Officer

Email: Mr Jim Bews

Tel: 01334 463830

The School's electron microscopy unit houses two high resolution transmission electron microscopes and a Jeol JSM-5600 scanning electron microscope. In both the JEM 2010 TEM and the JSM 5600 SEM, EDX (Energy Dispersive X-rays) systems for analytical elemental analysis are integrated within the microscopes. In the case of the TEM 2010, the ISIS system is installed and with the SEM 5600, the Inca Energy System.

Email: Dr W Zhou

Tel: 01334 467276

Located on level 1 of Purdie, Room 136.

Email: Mr Brian Walker

Tel: 01334 463797

• Agilent 7500 series ICP-MS spectrometer Solution: aqueous or organic matrix; Laser Ablation facility.
• Pye Unicam AAS spectrometer: AAS or FES.
• Perkin Elmer Lambda 35 UV/VIS spectrometer: Liquid or solid samples.
• Perkin Elmer Spectrum GX IR spectrometer: Large number of attachments.

Email:  Mrs Sylvia Williamson

Tel: Sylvia Williamson on 01334 463697

Glass-blowing repairs and orders. Please note: this service is only available to the School of Chemistry.

• Perkin Elmer minitrack (liquid handling robot) housed in a level two hood
• Perkin Elmer Envision plate reader
• Wallac Victor plate reader
• Level II biosafety cabinet.

Email: Dr N J Westwood

Tel: 01334 463816

The department has two mass spectrometers for service work. A Micromass GCT provides EI and CI at low and high resolution and a Micromass LCT provides a low and high resolution electrospray service.
Mass spectrometry form (PDF, 96 KB).

Email: Mrs Caroline Horsburgh

Tel: 01334 463790

Located on level 1 of Purdie, Room 137.

Email: Mr George Anthony and  Mr Robert Cathcart

Tel: 01334 463798

The School currently has six powder X-ray diffractometers. The current facility comprises two PANalytical Empyrean diffractometers, a Philips diffractometer operating in reflection geometry, and three Stoe diffractometers operating in transmission mode (capillary and flat-plate), one of which uses Fe rather than Cu radiation. Please consult the Powder Diffraction Website for important information.

Email: Dr Yuri Andreev

Tel: 01334 463814

Perkin Elmer System 2000 (FT)

Email: Prof J.D. Woollins

Tel: 01334 46 3861

The Chemical Crystallography currently has the following systems:

• STANDARD System (St Andrews Robotic Diffractometer consisting of Mo sealed tube X-Ray system with SHINE optic, Saturn CCD and ACTOR Robotic sample changer and XStream LT accessory
• Rigaku Cu MM007 high brilliance generator with Saturn 92 CCD and XStream LT accessory
• Rigaku Mo MM007 (dual port) high brilliance generator with Saturn 70 and Mercury CCD detectors and two XStream LT accessories.
• Rigaku SCX Mini, Mo Radiation SHINE Optic with Mercury CCD detector and XStream LT accessory.

Email: Prof Alex Slawin, (preferably by email in the first instance)

Tel: 01334 467280.

To make a request for an X-ray structure determination, please download the XRay Submission Form (Word, 36 KB).

A solid state NMR service is available on a 400MHz HFXY Bruker Avance III spectrometer. This spectrometer has four radio frequency channels and two dual channel probes (7mm and 4mm) for routine service work with MAS up to 18 kHz and HFXY capabilities.

Email: Dr Philip Wormald

Tel: 01334 463382

For more information on research in solid-state NMR at St Andrews, please refer to Dr Wormald's website and Dr Ashbrook's website

The department has five nuclear magnetic resonance spectrometers for solution NMR. Three instruments operate at 300 MHz for proton observation and the other two at 500 MHz. All the spectrometers have the capability of recording spectra above and below room temperature and the two Bruker Avance 300 spectrometers and the Bruker Avance 500 spectrometer are fully automated with autosampling robots. The Facility is capable of acquiring data on almost any nucleus and has extensive capabilities for triple resonance experiments.

See the website for more information.

Email: Dr Douglas Philp

Tel: 01334 467264

NMR JEOL GSX Delta 270

Email: Prof J.D. Woollins

Tel: 01334 463861

Stores are located on level 1 of Purdie, Room 134.

Opening hours:

• 09:00-12:00
• 14:00-16:00

Email: purdie-store@st-andrews.ac.uk

Web: http://chemistry.st-andrews.ac.uk/stores/

Tel: 01334 463784

The School currently has the following:

• Omicron UHV Scanning Tunneling Microscope (STM)
• Four Molecular Imaging STM instruments, all of which work in ambient and electrochemical environments and are also capable of Atomic Force Microscopy (AFM)
• An additional AFM instrument
• UHV Nicolet FTIR with polarisation modulation (PM) and ATR attachment
• An additional Digilab PM-FTIR system with facilities for sample analysis at the liquid-solid interface/electrochemical environments
• Laser system for Sum Frequency Generation/Second Harmonic Generation (SFG/SHG)
• UHV x-ray photoemission (XPS)
• Two UHV High Resolution Electron Energy Loss Spectroscopy (HREELS) systems
• UHV LEED/AES/TPD/high pressure cell + Gas chromatograph
• Tensiometer for contact angle measurements.
  

Email: Dr Steve Francis

Tel: 01334 462273

• Differential Scanning Calorimetry - Netzsch DSC 204 Instrument: Range -150 to 400C; high sensitivity.
• Perkin-Elmer DSC7: -110 to 440C
• Thermogravimetric Analysis - Netzsch STA 449C with Mass Spec: TGA/DSC or TGA/DTA under oxidising or reducing atmosphere to 1600C, coupled to a Pfeiffer mass spectrometer (200amu) for evolved gas analysis.
• TA Instruments SDT 2960: TGA/DTA under oxidising atmosphere to 1250C.
• Rheometrics TG 1000M: TGA under oxidising or reducing atmosphere, water cooled furnace allows rapid heating/cooling, can be run under wet atmosphere.
• Thermal Expansion - Netzsch Dilatometer DIL402C: Oxidising or reducing atmosphere to 1550C.
• Porosimetry - Hiden IGA porosimeter: Gas and vapour adsorption, BET analysis.

Email: Mrs Sylvia Williamson

Tel: 01334 463697