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Professor Verity Brown holds a Royal Society (Industry) Fellowship, working collaboratively with scientists at Organon Schering Plough (Newhouse, UK).
Her research is concerned with how the brain organizes responses and controls actions. The brain operates selectivity in many ways, but most obviously in the processing of inputs ("attention") and in the generation of responses, ensuring that choices are appropriate, timely and effective in achieving the desired outcomes or goals. The ultimate research aim is to understand the nature of these executive processes and how and why they sometimes fail. This has relevance for understanding the impairments in thought associated with human psychiatric disorders such as schizophrenia, depression and Alzheimer’s disease. She is particularly interested in making improvements in the efficiency, efficacy and validity of models used by the pharmaceutical industry in preclinical drug-development.
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vjb@st-andrews.ac.uk |
Tel:07792 383 103 (Mobile) |
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Tait, D.S., Marston, H.M., Shahid, M. and Brown, V.J. (2008) Asenapine restores cognitive flexibility in rats with lesions of the medial prefrontal cortex. Psychopharmacology, DOI: 10.1007/s00213-008-1364-8 |
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Tait, D.S., Brown, V.J. (2008) Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats. Behavioural Brain Research, 187, pp. 100-108. |
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O'Neill, M., Brown, V.J. (2007) The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats. Neurobiology of Learning and Memory, 88, pp. 75-81. |
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Tait, D.S., Brown, V.J., Farovik, A., Theobald, D.E., Dalley, J.W., Robbins, T.W. (2007) Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat. European Journal of Neuroscience, 25, pp. 3719-3724. |
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